Mickey's previous voluminous series of posts on this subject are listed here. He and others, most notably Dr Jon Jureidini, have attempted to get the journal that published the now widely ridiculed Study 329 retracted. His three recent posts on the subject are:
the lesson of Study 329: an unfinished symphony…
hide-and-go-seek…
a response…
In the most recent of these, he argued,
In this particular case, there are no facts in question. It was a negative trial, declared negative by the people who did it. The paper was ghost-written and reviewed by the sponsor before any of the twenty two authors ever saw a manuscript. The science was jury-rigged to imply a positive outcome where none was supported using well-documented sleight of hand. None of that is speculative. And the article has been a centerpiece for court settlements worth billions of dollars.
Yet, the Journal of the American Academy of Child and Adolescent Psychiatry refused to retract the article. Mickey's opinion in the second of the posts listed above,
One can only conclude that they found this article to be an inconvenient truth, and that Dr. Andres Martin and his colleagues in the American Academy of Child and Adolescent Psychiatry believe that acknowledging that truth would do more harm than good [or maybe even found a way not to see the truth at all, though it's hard to imagine how]. Sooner or later, this whole tawdry saga is going to find its way out of the blogs and courtrooms and into the full light of day. And the question that’s going to be asked is why didn’t Medicine itself deal with the problem? Why didn’t the Journal itself retract the misinformation once they knew about it? Why didn’t the industry sponsor itself call for the retraction as part of their settlement with the DOJ? What possible reasonable reason could there be for leaving a paper that is a lie in their journal without even an expression of concern, much less a retraction? And there aren’t going to be any believable answers.
Mickey concluded the most recent post,
The loser in this story is the American Academy of Child and Adolescent Psychiatry, and ultimately psychiatry itself…
The longer inconvenient truths are ignored or suppressed, the more inconvenient, and hazardous they will ultimately become.
ADDENDUM (26 December, 2012) - One more post on 1BoringOldMan: telling the truth as a liability…
Its conclusion
By any criteria, the conclusion to the 2001 Keller et al article is wrong ["Paroxetine is generally well tolerated and effective for major depression in adolescents"]. That’s not the reason that some of us have been so persistent in pushing for retraction. The reason is that it was wrong at the time the article was published, and they knew it was wrong, but published it anyway. We want to make a statement about the integrity of the scientific literature.
2 comments:
Man o man how sad. Is this predictable? What could physicians do, cancel their membership?
Why wouldn't they?
The primary reason I can think of for the firm refusal to retract this fraudulent study is that it is but one example of numerous such papers that infest the medical literature.
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